Review
doi: 10.1111/pcmr.12232.
Epub 2014 Mar 3.
Sun-induced freckling: ephelides and solar lentigines
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- PMID: 24517859
- DOI: 10.1111/pcmr.12232
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Review
Sun-induced freckling: ephelides and solar lentigines
Pigment Cell Melanoma Res.
2014 May.
Abstract
Freckles, the lay term for ephelides and lentigines, are important pigmentation characteristics observed in humans. Both are affected by sunlight; ephelides are largely genetically determined but induced by sunlight, whereas lentigines are induced by sun exposure and photodamage of the skin. However, despite being commonly observed, we know very little about them. Here, we review the current status of knowledge about freckles and propose a model for their formation.
Keywords: ephelides; freckles; melanocytes; solar lentigines; stem cells.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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