Crizotinib can overcome acquired resistance to CH5424802: is amplification of the MET gene a key factor?

J Thorac Oncol. 2014 Mar;9(3):e27-8. doi: 10.1097/JTO.0000000000000113.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Carbazoles / pharmacology*
  • Crizotinib
  • Disseminated Intravascular Coagulation / drug therapy*
  • Disseminated Intravascular Coagulation / genetics
  • Disseminated Intravascular Coagulation / pathology
  • Drug Resistance, Neoplasm / drug effects*
  • Drug Resistance, Neoplasm / genetics
  • Gene Amplification*
  • Humans
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / secondary
  • Piperidines / pharmacology*
  • Prognosis
  • Protein Kinase Inhibitors / therapeutic use
  • Proto-Oncogene Proteins c-met / genetics*
  • Pyrazoles / therapeutic use*
  • Pyridines / therapeutic use*

Substances

  • Carbazoles
  • Piperidines
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyridines
  • Crizotinib
  • MET protein, human
  • Proto-Oncogene Proteins c-met
  • alectinib