PHIPing out: a genetic basis for tumor ulceration

J Invest Dermatol. 2014 Mar;134(3):600-602. doi: 10.1038/jid.2013.443.


Ulceration is a common negative prognostic marker of solid tumors including melanoma. The signaling basis of ulceration is being elucidated. PHIP has been found to be amplified in wild-type melanomas, resulting in Akt activation and aerobic glycolysis (Warburg effect), associated with ulceration. The ulceration phenotype likely represents the genotype of the reactive oxygen driven tumor, in which reactive oxygen drives angiopoietin-2 production, tumor growth, and invasion. This phenotype is amenable to pharmacologic intervention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Male
  • Melanoma / genetics*
  • Skin Neoplasms / genetics*
  • Skin Ulcer / genetics*


  • Intracellular Signaling Peptides and Proteins
  • PHIP protein, human