Objective: To evaluate the value of urine Livin and Survivin mRNA expression in the early diagnosis of bladder cancer.
Methods: Fifty-two cases of early bladder cancer and 30 cases of non-urinary system tumors were selected for the combined detection of urinary Livin and Survivin and urine cytology.
Results: Livin and Survivin in urine and urinary cytology sensitivity were 71.2% (37/52) , 67.3% (35/52), 23.1% (12/52); Specificity were 96.7% (29/30) , 93.3% (28/30) and 96.7% (29/30) respectively. Urine Survivin sensitivity, specificity compared with Livin were no significant difference (all P > 0.05). Urinary Livin and Survivin were more sensitive than urine cytology, and the differences were statistically significant(all P < 0.05).
Conclusion: The combined urinary detection of Livin, Survivin mRNA expression is a noninvasive early diagnosis of bladder cancer with sensitivity and specificity.