Core drug-drug interaction alerts for inclusion in pediatric electronic health records with computerized prescriber order entry

J Patient Saf. 2014 Mar;10(1):59-63. doi: 10.1097/PTS.0000000000000050.


Objective: The study aims to develop a core set of pediatric drug-drug interaction (DDI) pairs for which electronic alerts should be presented to prescribers during the ordering process.

Methods: A clinical decision support working group composed of Children's Hospital Association (CHA) members was developed. CHA Pharmacists and Chief Medical Information Officers participated.

Results: Consensus was reached on a core set of 19 DDI pairs that should be presented to pediatric prescribers during the order process.

Conclusions: We have provided a core list of 19 high value drug pairs for electronic drug-drug interaction alerts to be recommended for inclusion as high value alerts in prescriber order entry software used with a pediatric patient population. We believe this list represents the most important pediatric drug interactions for practical implementation within computerized prescriber order entry systems.

MeSH terms

  • Adverse Drug Reaction Reporting Systems / statistics & numerical data*
  • Child
  • Child Welfare / statistics & numerical data
  • Drug Interactions*
  • Drug Therapy, Computer-Assisted / standards*
  • Drug Therapy, Computer-Assisted / statistics & numerical data
  • Electronic Health Records
  • Female
  • Humans
  • Male
  • Medical Order Entry Systems / standards*
  • Medical Order Entry Systems / statistics & numerical data
  • Medication Errors / prevention & control*
  • Pediatrics
  • United States