Irreversible enzyme inhibition kinetics and drug-drug interactions

Methods Mol Biol. 2014;1113:57-91. doi: 10.1007/978-1-62703-758-7_5.


This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.

Publication types

  • Review

MeSH terms

  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Design
  • Drug Interactions
  • Enzyme Inhibitors / pharmacology*
  • Enzymes / metabolism*
  • Humans
  • Kinetics


  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Enzymes
  • Cytochrome P-450 Enzyme System