Neurogenesis and maturation in neonatal brain injury

Clin Perinatol. 2014 Mar;41(1):229-39. doi: 10.1016/j.clp.2013.10.007. Epub 2013 Dec 15.


The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. Several animal models have been employed to study the consequences of prematurity, one of the most promising being chronic perinatal hypoxia in mouse, which recapitulates the cognitive impairments, partial recovery over time and enhanced recovery with environmental enrichment.

Keywords: Cognitive delay; Neonatal brain injury; Neurogenesis; Preterm birth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astrocytes / cytology*
  • Brain / embryology
  • Brain / growth & development*
  • Brain Injuries / physiopathology*
  • Developmental Disabilities / physiopathology*
  • Disease Models, Animal
  • Gestational Age
  • Humans
  • Hypoxia, Brain / physiopathology*
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight
  • Neurogenesis / physiology*