Gene regulatory networks and transcriptional mechanisms that control myogenesis

Dev Cell. 2014 Feb 10;28(3):225-38. doi: 10.1016/j.devcel.2013.12.020.


We discuss the upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model. Key upstream genes, such as Pax3 and Pax7, Six1 and Six4, or Pitx2, participate in gene regulatory networks at different sites of skeletal muscle formation. MicroRNAs also intervene, with emerging evidence for the role of other noncoding RNAs. Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental*
  • Gene Regulatory Networks*
  • Humans
  • Muscle Development / genetics*
  • Transcription Factors
  • Transcription, Genetic*


  • Transcription Factors