Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

Kardiol Pol. 2014;72(8):735-9. doi: 10.5603/KP.a2014.0048. Epub 2014 Feb 14.


Background: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalized due to AHF.

Aim: To study the association between baseline GGT activity and in-hospital mortality in AHF patients.

Methods: The study cohort consisted of 183 AHF patients with left ventricular ejection fraction (LVEF) < 50%. The primary endpoint was in-hospital mortality. Patients were divided into two groups according to in-hospital mortality. The relationship between GGT activity and in-hospital mortality was tested using logistic regression models, adjusting for clinical characteristics and echocardiographic findings.

Results: After adjustment for possible confounders, GGT level was significantly related (OR 1.056, 95% CI 1.018-1.096, p = 0.04) to in-hospital mortality.

Conclusions: Elevated GGT activity is an independent predictor of short-term mortality in patients with AHF and reduced LVEF.

MeSH terms

  • Acute Disease
  • Cohort Studies
  • Female
  • Heart Failure / enzymology*
  • Heart Failure / mortality*
  • Hospital Mortality*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • gamma-Glutamyltransferase / blood*


  • gamma-Glutamyltransferase