The clinical effectiveness in wound healing with extracellular matrix derived from porcine urinary bladder matrix: a case series on severe chronic wounds

Howard Kimmel; Michael Rahn; Thomas W Gilbert

doi:10.1016/j.jcws.2010.11.002

The clinical effectiveness in wound healing with extracellular matrix derived from porcine urinary bladder matrix: a case series on severe chronic wounds

J Am Col Certif Wound Spec. 2010 Nov 30;2(3):55-9. doi: 10.1016/j.jcws.2010.11.002. eCollection 2010 Sep.

Authors

Howard Kimmel¹, Michael Rahn¹, Thomas W Gilbert²

Affiliations

¹ Louis Stokes Department of Veterans Affairs, Cleveland, Ohio 44106, USA.
² McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Abstract

A study involving 3 patients was performed to evaluate the efficacy of Matristem, an extracellular matrix scaffold derived from the porcine urinary bladder matrix (UBM), to promote natural healing in patients with severe, chronic wounds that did not respond well to standard wound management. In all cases, the wounds closed after only a few weeks of repeated treatments with UBM, with all patients showing complete epithelialization of the wound with limited formation of scar tissue by 13 weeks after first treatment. These initial results suggest that UBM warrants further investigation for treatment of chronic nonhealing ulcers that are recalcitrant to standard wound therapies.

Keywords: Extracellular matrix scaffold; Urinary bladder matrix; Wound care.