From arrest to escape: HIV-1 Vpr cuts a deal

Cell Host Microbe. 2014 Feb 12;15(2):125-7. doi: 10.1016/j.chom.2014.01.012.

Abstract

HIV Vpr induces a cell-cycle arrest at the G2-to-M transition through a poorly understood mechanism. In a recent issue of Cell, Laguette et al. (2014) demonstrate that untimely activation of the structure-specific endonuclease regulator SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

Publication types

  • Comment

MeSH terms

  • G2 Phase Cell Cycle Checkpoints*
  • HIV Infections / pathology*
  • HIV-1 / metabolism*
  • Humans
  • Immunity, Innate*
  • Multiprotein Complexes / metabolism*
  • Recombinases / metabolism*
  • vpr Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

  • Multiprotein Complexes
  • Recombinases
  • vpr Gene Products, Human Immunodeficiency Virus

Grants and funding