Mood disorders after TBI

Psychiatr Clin North Am. 2014 Mar;37(1):13-29. doi: 10.1016/j.psc.2013.11.005. Epub 2014 Jan 14.


In this article, we examine the epidemiology and risk factors for the development of the most common mood disorders observed in the aftermath of TBI: depressive disorders and bipolar spectrum disorders. We describe the classification approach and diagnostic criteria proposed in the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders. We also examine the differential diagnosis of post-TBI mood disorders and describe the mainstay of the evaluation process. Finally, we place a special emphasis on the analysis of the different therapeutic options and provide guidelines for the appropriate management of these conditions.

Keywords: Depressive disorders; Mood disorders; Traumatic brain injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aggression / psychology
  • Anxiety Disorders / epidemiology
  • Brain Injuries / complications*
  • Brain Injuries / psychology
  • Cognitive Behavioral Therapy
  • Comorbidity
  • Diagnosis, Differential
  • Electroconvulsive Therapy
  • Humans
  • Impulsive Behavior / epidemiology
  • Mood Disorders* / diagnosis
  • Mood Disorders* / epidemiology
  • Mood Disorders* / etiology
  • Mood Disorders* / therapy
  • Patient Education as Topic
  • Psychotropic Drugs / therapeutic use*
  • Substance-Related Disorders / epidemiology


  • Psychotropic Drugs