Comparison of the effect of sertraline with behavioral therapy on semen parameters in men with primary premature ejaculation

Urology. 2014 Apr;83(4):800-4. doi: 10.1016/j.urology.2013.12.004. Epub 2014 Feb 12.


Objective: To investigate the effects of sertraline on semen parameters and comparison of its effect with behavioral therapy (BT) in men with primary premature ejaculation.

Methods: In this single-blinded clinical trial, a total of 60 married men with primary premature ejaculation were randomly divided into 2 groups: the sertraline group (n = 30, sertraline 25 mg/day for 1 week followed by 50 mg/day for 3 months) and the BT group (n = 30, using BT technique for 3 months). Semen analysis was applied, and the results were compared between groups before and 3 months after intervention.

Results: The significant reduction in sperm concentration (10(5)/mL) and percentage of normal morphology was reported in sertraline group (P <.05). The percentage of sperm deoxyribonucleic acid fragmentation after intervention in sertraline group was significantly higher than BT group (P = .004). There was no significant change in semen parameters in patients treated using BT.

Conclusion: Our study revealed detrimental effects of sertraline on some semen parameters. It should particularly be considered in patients who are trying to conceive. It seems BT is a safe method without any side effect on semen analysis parameters.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Behavior Therapy / methods*
  • DNA Fragmentation / drug effects
  • Humans
  • Male
  • Premature Ejaculation / drug therapy*
  • Premature Ejaculation / psychology
  • Premature Ejaculation / therapy*
  • Prevalence
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Semen / drug effects*
  • Sertraline / adverse effects
  • Sertraline / pharmacology*
  • Single-Blind Method
  • Spermatozoa / drug effects
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Serotonin Uptake Inhibitors
  • Sertraline