Microtubule plus-end tracking proteins and their roles in cell division

Int Rev Cell Mol Biol. 2014;309:59-140. doi: 10.1016/B978-0-12-800255-1.00002-8.

Abstract

Microtubules are cellular components that are required for a variety of essential processes such as cell motility, mitosis, and intracellular transport. This is possible because of the inherent dynamic properties of microtubules. Many of these properties are tightly regulated by a number of microtubule plus-end-binding proteins or +TIPs. These proteins recognize the distal end of microtubules and are thus in the right context to control microtubule dynamics. In this review, we address how microtubule dynamics are regulated by different +TIP families, focusing on how functionally diverse +TIPs spatially and temporally regulate microtubule dynamics during animal cell division.

Keywords: +TIPs; Cytokinesis; Microtubule; Mitosis; Mitotic spindle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Division*
  • Humans
  • Microtubule-Associated Proteins / chemistry
  • Microtubule-Associated Proteins / metabolism*
  • Microtubules / metabolism*
  • Mitosis

Substances

  • Microtubule-Associated Proteins