[Hypovitaminosis D and Metabolic Syndrome]

Med Clin (Barc). 2014 Dec 23;143(12):542-7. doi: 10.1016/j.medcli.2013.12.012. Epub 2014 Feb 14.
[Article in Spanish]


Metabolic syndrome and hypovitaminosis D are 2 diseases with high prevalence that share several risk factors, while epidemiological evidence shows they are associated. Although the mechanisms involved in this association are not well established, hypovitaminosis D is associated with insulin resistance, decreased insulin secretion and activation of the renin-angiotensin system, mechanisms involved in the pathophysiology of metabolic syndrome. However, the apparent ineffectiveness of vitamin D supplementation on metabolic syndrome components, as well as the limited information about the effect of improving metabolic syndrome components on vitamin D concentrations, does not clarify the direction and the mechanisms involved in the causal relationship between these 2 pathologies. Overall, because of the high prevalence and the epidemiological association between both diseases, hypovitaminosis D could be considered a component of the metabolic syndrome.

Keywords: Diabetes; Metabolic syndrome; Síndrome metabólico; Vitamin D; Vitamina D.

Publication types

  • Review

MeSH terms

  • Biomarkers / metabolism
  • Humans
  • Insulin Resistance
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / metabolism
  • Renin-Angiotensin System / physiology
  • Risk Factors
  • Vitamin D / metabolism
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / metabolism


  • Biomarkers
  • Vitamin D