Galectin-3 in cancer

Clin Chim Acta. 2014 Apr 20:431:185-91. doi: 10.1016/j.cca.2014.01.019. Epub 2014 Feb 12.


Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-3 as well as its potential action mechanism in tumorigenesis in a variety of cancers were summarized and concluded. Gal-3 is gaining its attraction as a potential new biomarker for the diagnosis, treatment and prognosis of certain tumors.

Keywords: Cancer; Expression; Galectin-3 (Gal-3); Location; Mechanism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Galectin 3 / analysis
  • Galectin 3 / genetics*
  • Galectin 3 / physiology*
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Prognosis


  • Biomarkers, Tumor
  • Galectin 3