Getting myosin-V on the right track: tropomyosin sorts transport in yeast

Bioarchitecture. Jan-Feb 2014;4(1):35-8. doi: 10.4161/bioa.28204. Epub 2014 Feb 14.

Abstract

Recent studies have revealed a novel mechanism of myosin regulation in which the actin-binding protein tropomyosin converts atypical type-V myosins into processive cargo transporters. To achieve this, tropomyosin's primary role appears to lie in its ability to influence myosin's enzyme kinetics, prolonging the strong actin-bound ADP/apo state to enable hand-over-hand walking of myosin-V dimers along actin tracks. Activation of myosin-V mediated transport by tropomyosin underscores its function in helping to direct cargos to specific actin tracks and subcellular destinations. This type of regulation supports the broader notion that tropomyosin plays a key role in actomyosin sorting.

Keywords: actin; actomyosin sorting; duty ratio; intracellular transport; myosin-V; processivity; tropomyosin.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Myosins / metabolism*
  • Schizosaccharomyces / metabolism*
  • Schizosaccharomyces pombe Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • Schizosaccharomyces pombe Proteins
  • Myosins