Effect of landiolol hydrochloride after off-pump coronary artery bypass

Asian Cardiovasc Thorac Ann. 2013 Apr;21(2):170-5. doi: 10.1177/0218492312450865.


Objectives: many studies have shown that oral beta blockers reduce the incidence of atrial fibrillation after coronary artery bypass. The goal of this study was to determine whether landiolol, an intravenous beta blocker, reduces the incidence of atrial fibrillation after off-pump coronary artery bypass.

Methods: 39 consecutive patients were given landiolol after coronary artery bypass, and 20 who were not given landiolol served as a control group. Landiolol was intravenously administered at 1 µg.kg(-1).min(-1) in the intensive care unit.

Results: the mean dose of landiolol was 2.3 ± 1.2 1 µg.kg(-1).min(-1). The incidence of atrial fibrillation during intensive care unit stay was significantly lower in the landiolol group compared to the control group: 2.6% (1/39) vs. 20% (4/20). Heart rate after landiolol administration was significantly lower than that before administration, whereas landiolol had no effect on blood pressure. C-reactive protein and creatine kinase levels 7 days after surgery were significantly lower in the landiolol group.

Conclusion: continuous administration of landiolol at a low dose after off-pump coronary artery bypass reduced the incidence of atrial fibrillation.

Keywords: Landiolol [Supplementary Concept]; adrenergic beta-antagonists; atrial fibrillation; coronary artery bypass; perioperative care.

MeSH terms

  • Adrenergic beta-Antagonists / administration & dosage*
  • Adrenergic beta-Antagonists / adverse effects
  • Aged
  • Anti-Arrhythmia Agents / administration & dosage*
  • Anti-Arrhythmia Agents / adverse effects
  • Atrial Fibrillation / diagnosis
  • Atrial Fibrillation / epidemiology
  • Atrial Fibrillation / physiopathology
  • Atrial Fibrillation / prevention & control*
  • Coronary Artery Bypass, Off-Pump / adverse effects*
  • Drug Administration Schedule
  • Female
  • Heart Rate / drug effects
  • Humans
  • Incidence
  • Infusions, Intravenous
  • Intensive Care Units
  • Japan / epidemiology
  • Length of Stay
  • Male
  • Middle Aged
  • Morpholines / administration & dosage*
  • Morpholines / adverse effects
  • Time Factors
  • Treatment Outcome
  • Urea / administration & dosage
  • Urea / adverse effects
  • Urea / analogs & derivatives*


  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Morpholines
  • landiolol
  • Urea