Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors

J Leukoc Biol. 2014 Apr;95(4):551-62. doi: 10.1189/jlb.1113599. Epub 2014 Feb 14.


MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.

Keywords: antigen processing; compartmentalization; cotranslational degradation; nuclear translation; ribosome; translation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Mediator Complex
  • Monitoring, Immunologic*
  • Neoplasms / immunology*
  • Protein Biosynthesis*
  • Ribosomes / immunology*


  • DRIP, VDR interacting protein complex
  • Histocompatibility Antigens Class I
  • Mediator Complex