Joint effects of alcohol consumption and ABCG2 Q141K on chronic tophaceous gout risk

J Rheumatol. 2014 Apr;41(4):749-58. doi: 10.3899/jrheum.130870. Epub 2014 Feb 15.

Abstract

Objective: To investigate the joint effects of alcohol consumption and ABCG2 gene variants on tophaceous gout occurrence.

Methods: The V12M (rs2231137), Q126X (rs72552713), and Q141K (rs2231142) of the ABCG2 gene were genotyped among controls, nontophaceous, and tophaceous gout cases in Taiwanese Han (n=446, 77, 177) and Taiwan Aborigines (n=1105, 203, 330).

Results: The missense variations V12M (C) and Q141K (T) significantly associated with tophaceous gout (p trend=4.08×10(-2), 9.00×10(-12) in Han; 1.81×10(-3), 9.34×10(-10) in Aborigines). The nonsense variation Q126X (T) exerted a significant effect only in Han (p=1.10×10(-2)), but not in Aborigines. In the prediction of tophaceous gout, the Q141K (T) OR were 1.51 in Han, 1.50 in Aborigines, and 1.55 (p=7.84×10(-5)) in pooled analysis when compared to nontophaceous gout. We found the joint effects of alcohol consumption and Q141K (T/T) highly associated with tophaceous gout (adjusted OR≥5.11; p≤7.78×10(-4)); specifically the ever drinkers carrying the Q141K (T/T; adjusted OR 25.05, p=9.21×10(-4) in Han; adjusted OR 14.87, p=1.08×10(-8) in Aborigines).

Conclusion: Our findings showed alcohol consumption and ABCG2 Q141K, independently and jointly, associated with the risk of chronic tophaceous gout.

Keywords: ABCG2 Q141K; ALCOHOL CONSUMPTION; TOPHACEOUS GOUT.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters / genetics*
  • Adult
  • Aged
  • Alcohol Drinking / adverse effects*
  • Case-Control Studies
  • Chronic Disease
  • Female
  • Genetic Predisposition to Disease / epidemiology*
  • Gout / etiology
  • Gout / genetics*
  • Humans
  • Hyperuricemia / etiology
  • Hyperuricemia / genetics*
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Mutation, Missense
  • Neoplasm Proteins / genetics*
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Risk Assessment
  • Taiwan

Substances

  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters
  • Neoplasm Proteins