Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development

Cell. 1988 May 20;53(4):617-25. doi: 10.1016/0092-8674(88)90577-6.


The mouse genome contains at least three copies of sequences homologous to the "paired box", a conserved domain in several Drosophila segmentation genes of the pair-rule and segment polarity classes. Overlapping phages were isolated from two different genomic libraries using the Drosophila gooseberry distal paired box as a probe. The hybridizing sequences are highly homologous to the conserved Drosophila paired box sequences. A single 3.1 kb Pax 1 (paired box gene) transcript was detected during embryonic development, whereas no transcripts were detected in adult tissues. Detailed in situ hybridization analyses with frozen embryonic sections demonstrated Pax 1 transcripts in the perichordal zone of the developing vertebral column. The expression pattern suggests a role for this gene in the formation of segmented structures of the mouse embryo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA / genetics
  • Gene Expression Regulation*
  • Genes, Homeobox*
  • Mice
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • RNA / genetics
  • Sequence Homology, Nucleic Acid


  • RNA
  • DNA

Associated data

  • GENBANK/M20978