Activation of the mas oncogene during transfection of monoblastic cell line DNA

Leukemia. 1988 May;2(5):318-20.


Using the tumorigenicity assay, we observed an activation of the mas oncogene during transfection of human acute myelocytic leukemia (CTV-2) DNA. Respective transfectants contained amplified mas sequences characterized by rearrangements in 5' and 3' noncoding regions that were transcribed into a 3.3 kb mas RNA species. Our data represent the second report on activation of the mas gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA Restriction Enzymes / metabolism
  • DNA, Neoplasm / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Mice
  • Mice, Nude
  • Oncogenes*
  • Poly A / analysis
  • RNA / analysis
  • RNA, Messenger
  • Transfection*


  • DNA, Neoplasm
  • RNA, Messenger
  • Poly A
  • RNA
  • DNA Restriction Enzymes