Three types of vitronectin in human blood

Cell Struct Funct. 1988 Apr;13(2):123-8. doi: 10.1247/csf.13.123.


Vitronectin is a cell-adhesive glycoprotein in serum and plasma, also termed serum spreading factor and complement S-protein. It consists of a mixture of a polypeptide of molecular weight 75 kilodalton (kDa) and its nicked product of 65 kDa plus 10 kDa. By a quantitative immunoblotting assay, human blood samples could be classified into three distinct vitronectin types; type I (58% of the population) was 75 kDa rich and 65 kDa poor, type II (35% of the population) contained approximately equal amounts of 75 kDa and 65 kDa, and type III (5% of the population) was 75 kDa poor and 65 kDa rich. The vitronectin type did not correlate with age, sex, or ABO blood type.

MeSH terms

  • ABO Blood-Group System
  • Adult
  • Age Factors
  • Aged
  • Female
  • Glycoproteins / analysis
  • Glycoproteins / blood*
  • Glycoproteins / immunology
  • Humans
  • Male
  • Middle Aged
  • Molecular Weight
  • Sex Factors
  • Vitronectin


  • ABO Blood-Group System
  • Glycoproteins
  • Vitronectin