Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens

Eur J Immunol. 1988 Jun;18(6):969-72. doi: 10.1002/eji.1830180622.


In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Bacterial / analysis*
  • Antigens, Bacterial / immunology
  • Antigens, Differentiation, T-Lymphocyte* / immunology
  • Cells, Cultured
  • Cytotoxicity, Immunologic*
  • Epitopes / immunology
  • Mice
  • Mice, Inbred C57BL
  • Mycobacterium leprae / immunology*
  • Phenotype
  • Schwann Cells / immunology*
  • T-Lymphocytes, Cytotoxic / classification*
  • T-Lymphocytes, Cytotoxic / immunology


  • Antigens, Bacterial
  • Antigens, Differentiation, T-Lymphocyte
  • Epitopes