The Angiomotins--from discovery to function

FEBS Lett. 2014 Aug 19;588(16):2693-703. doi: 10.1016/j.febslet.2014.02.006. Epub 2014 Feb 15.

Abstract

Angiomotins were originally identified as angiostatin binding proteins and implicated in the regulation of endothelial cell migration. Recent studies have shed light on the role of Angiomotins and other members of the Motin protein family in epithelial cells and in pathways directly linked to the pathogenesis of cancer. In particular, Motins have been shown to play a role in signaling pathways regulated by small G-proteins and the Hippo-YAP pathway. In this review the role of the Motin protein family in these signaling pathways will be described and open questions will be discussed.

Keywords: Angiomotin; Angiomotin-like 1; Angiomotin-like 2; Hippo; Merlin; Motin; NF2; YAP.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease
  • Endothelial Cells / metabolism
  • Gene Expression Regulation
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Membrane Proteins / metabolism*
  • Microfilament Proteins
  • Neovascularization, Physiologic
  • Signal Transduction

Substances

  • AMOT protein, human
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Microfilament Proteins