Interferons

Immunol Suppl. 1988;1:43-5.

Abstract

Interferon (IFN)-alpha and -beta are produced by virus-infected cells; IFN-gamma is produced as a primary response of T lymphocytes to mitogenic stimulation, IFN-gamma gene activation being brought about by changes in Ca2+ and phosphatidyl inositol metabolism. IFNs act by binding to cell surface receptors and triggering activation of IFN-responsive genes, probably via specific base sequences located in the 5' non-coding region of such genes, resulting in changes in cell function. Important genes activated in this way are the MHC antigen genes; class I induced by all IFNs, class II by IFN-gamma only. This MHC activation may have important consequences for lymphocyte function.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemical Phenomena
  • Chemistry
  • HLA Antigens / immunology
  • Interferons / biosynthesis
  • Interferons / physiology*
  • Mice

Substances

  • HLA Antigens
  • Interferons