Imaging in living cells using νB-H Raman spectroscopy: monitoring COSAN uptake

Chem Commun (Camb). 2014 Mar 28;50(25):3370-2. doi: 10.1039/c3cc49658a. Epub 2014 Feb 18.

Abstract

The boron-rich cobaltabisdicarbollide (COSAN) and its 8,8'-I2 derivative (I2-COSAN), both of purely inorganic nature, are shown to accumulate within living cells, where they can be detected using νB-H Raman microspectroscopy. This demonstrates an alternative method for cell labelling and detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Boron / chemistry
  • HEK293 Cells
  • Humans
  • Organometallic Compounds / pharmacology*
  • Spectrum Analysis, Raman / methods
  • Staining and Labeling / methods*

Substances

  • Organometallic Compounds
  • cobaltabisdicarbollide anion
  • Boron