3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs

Adv Mater. 2014 May 21;26(19):3124-30. doi: 10.1002/adma.201305506. Epub 2014 Feb 18.


A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

Keywords: 3D printing; biomaterials; bioprinting; tissue engineering; vasculature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bioprinting*
  • Extracellular Matrix / chemistry
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Poloxamer / chemistry
  • Polyethylene Glycols / chemistry
  • Propylene Glycols / chemistry
  • Tissue Engineering


  • Propylene Glycols
  • Poloxamer
  • Polyethylene Glycols