[6]-gingerol as a cancer chemopreventive agent: a review of its activity on different steps of the metastatic process

Mini Rev Med Chem. 2014 Apr;14(4):313-21. doi: 10.2174/1389557514666140219095510.

Abstract

For many years, ginger or ginger root, the rhizome of the plant Zingiber officinale, has been consumed as a delicacy, medicine, or spice. Several studies have been conducted on the medicinal properties of ginger against various disorders, including cancer. Cancer is the second leading cause of death, and chemoprevention is defined as the use of natural or synthetic substances to prevent cancer initiation or progression. Evidence that ginger-derived compounds have inhibitory effects on various cancer cell types is increasingly being reported in the scientific literature. In this review we focused on the cancer chemopreventive effects of [6]-gingerol, the major pungent component of ginger, and its impact on different steps of the metastatic process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inducing Agents / chemistry
  • Angiogenesis Inducing Agents / pharmacology
  • Animals
  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / pharmacology*
  • Anticarcinogenic Agents / therapeutic use
  • Apoptosis / drug effects*
  • Catechols / chemistry
  • Catechols / pharmacology*
  • Catechols / therapeutic use
  • Cell Movement / drug effects*
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / pharmacology*
  • Fatty Alcohols / therapeutic use
  • Ginger / chemistry
  • Ginger / metabolism
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / prevention & control*
  • Reactive Oxygen Species / metabolism

Substances

  • Angiogenesis Inducing Agents
  • Anticarcinogenic Agents
  • Catechols
  • Fatty Alcohols
  • Reactive Oxygen Species
  • gingerol