Metabolic Syndrome and Polycystic Ovary Syndrome: An Intriguing Overlapping

Gynecol Endocrinol. 2014 Jun;30(6):397-402. doi: 10.3109/09513590.2014.887673. Epub 2014 Feb 19.


Metabolic syndrome is an increasing pathology in adults and in children, due to a parallel rise of obesity. Sedentary lifestyle, food habits, cultural influences and also a genetic predisposition can cause dyslipidemia, hypertension, abdominal obesity and insulin resistance which are the two main features of metabolic syndrome. Polycystic ovary syndrome (PCOS) is a condition directly associated with obesity, insulin resistance (HOMA index) and metabolic syndrome, and it is very interesting for its relationship and overlap with the metabolic syndrome. The relationship between the two syndromes is mutual: PCOS women have a higher prevalence of metabolic syndrome and also women with metabolic syndrome commonly present the reproductive/endocrine trait of PCOS. Prevention and treatment of metabolic syndrome and PCOS are similar for various aspects. It is necessary to treat excess adiposity and insulin resistance, with the overall goals of preventing cardiovascular disease and type 2 diabetes and improving reproductive failure in young women with PCOS. First of all, lifestyle changes, then pharmacological therapy, bariatric surgery and laparoscopic ovarian surgery represent the pillars for PCOS treatment.

Keywords: BMI; HOMA; PCOS; lifestyle; metabolic syndrome; therapy.

Publication types

  • Review

MeSH terms

  • Adiposity
  • Combined Modality Therapy
  • Female
  • Humans
  • Insulin Resistance
  • Life Style
  • Metabolic Syndrome / etiology*
  • Metabolic Syndrome / prevention & control
  • Models, Biological*
  • Obesity / metabolism
  • Obesity / pathology
  • Obesity / physiopathology*
  • Obesity / therapy
  • Polycystic Ovary Syndrome / etiology*
  • Polycystic Ovary Syndrome / prevention & control
  • Polycystic Ovary Syndrome / therapy
  • Theca Cells / metabolism
  • Theca Cells / pathology