Classics in chemical neuroscience: diazepam (valium)

ACS Chem Neurosci. 2014 Apr 16;5(4):253-60. doi: 10.1021/cn5000056. Epub 2014 Feb 27.


Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.

Publication types

  • Review

MeSH terms

  • Anxiety Disorders / drug therapy*
  • Diazepam / administration & dosage*
  • Diazepam / adverse effects*
  • Dose-Response Relationship, Drug
  • Drug Design
  • Drug Overdose / etiology*
  • Drug Overdose / prevention & control
  • Humans
  • Respiration Disorders / chemically induced*
  • Respiration Disorders / prevention & control
  • Seizures / chemically induced*
  • Seizures / prevention & control


  • Diazepam