Alkaloids from Boophone haemanthoides (Amaryllidaceae)

Nat Prod Commun. 2013 Dec;8(12):1705-10.

Abstract

In this study, the South African Amaryllid Boophone haemanthoides was examined for its phytochemical composition and cytotoxicity. In the process eight alkaloid structures, including the new compound distichaminol, were identified in bulb ethanolic extracts. Of the isolates, lycorine and distichamine exhibited strong activities against human acute lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7) and cervical adenocarcinoma (HeLa) cells with IC50S ranging from 1.8 to 9.2 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amaryllidaceae Alkaloids / chemistry
  • Amaryllidaceae Alkaloids / isolation & purification*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Liliaceae / chemistry*
  • MCF-7 Cells
  • Molecular Structure
  • Phenanthridines / isolation & purification

Substances

  • Amaryllidaceae Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Phenanthridines
  • lycorine