A new xanthone from the pericarp of Garcinia mangostana

Nat Prod Commun. 2013 Dec;8(12):1733-4.

Abstract

A new prenylxanthone, garcimangostanol (1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and garcinone C (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR and MS data. Compounds 1-4 exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Drug Screening Assays, Antitumor
  • Fruit / chemistry
  • Garcinia mangostana / chemistry*
  • Hep G2 Cells
  • Humans
  • MCF-7 Cells
  • Xanthones / chemistry
  • Xanthones / isolation & purification*

Substances

  • Antineoplastic Agents, Phytogenic
  • Xanthones
  • garcimangostanol