Anti-allergic inflammatory effects of cyanogenic and phenolic glycosides from the seed of Prunus persica

Nat Prod Commun. 2013 Dec;8(12):1739-40.

Abstract

A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1-3) and other phenolic compounds (4-8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1-8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-alpha and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / isolation & purification*
  • Glycosides / isolation & purification*
  • Histamine Antagonists / isolation & purification*
  • Humans
  • Phenols / isolation & purification*
  • Prunus / chemistry*
  • Seeds / chemistry

Substances

  • Anti-Inflammatory Agents
  • Glycosides
  • Histamine Antagonists
  • Phenols
  • cyanogenic glycosides