Abstract
A copper(I)-catalyzed, regioselective C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds using Togni's reagent was developed. Diverse substrates, including enones as well as α,β-unsaturated esters, thioesters, and amides, stereospecifically afforded the corresponding (E)-α-trifluoromethylated products in moderate to high yields. Further, this method was applied to the C-H trifluoromethylation of drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Catalysis
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Copper / chemistry*
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry
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Indicators and Reagents
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Iodides / chemistry*
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Ketones / chemical synthesis*
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Ketones / chemistry*
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Molecular Structure
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Stereoisomerism
Substances
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Amides
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Hydrocarbons, Fluorinated
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Indicators and Reagents
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Iodides
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Ketones
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Copper
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cuprous iodide