Organization of the mouse and human DC network

Curr Opin Immunol. 2014 Feb;26:90-9. doi: 10.1016/j.coi.2013.11.002. Epub 2013 Dec 3.

Abstract

Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in the body and are able to both initiate and fine-tune complex immune responses on a multitude of levels. In this review, we outline recent advances in our understanding of the organization of the DC network in mice and humans, the functional specialization of the DC subsets that compose these networks, and how this has enabled us to begin to elucidate cross-species parallels. Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / biosynthesis
  • Antigens, CD1 / biosynthesis
  • Antigens, Surface / biosynthesis
  • CD11b Antigen / biosynthesis
  • CD8 Antigens / biosynthesis
  • Cell Polarity / immunology
  • Cross-Priming / immunology
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism*
  • Glycoproteins / biosynthesis
  • Humans
  • Immunity, Cellular
  • Inflammation / immunology
  • Inflammation / pathology
  • Integrin alpha Chains / biosynthesis
  • Mice
  • Th17 Cells / immunology

Substances

  • Antigens, CD
  • Antigens, CD1
  • Antigens, Surface
  • CD11b Antigen
  • CD1C protein, human
  • CD8 Antigens
  • CD8alpha antigen
  • Glycoproteins
  • Integrin alpha Chains
  • THBD protein, human
  • alpha E integrins