Saccharomyces cerevisiae essential genes with an Opi- phenotype

G3 (Bethesda). 2014 Apr 16;4(4):761-7. doi: 10.1534/g3.113.010140.


The overproduction and secretion of inositol (i.e., Opi(-)) phenotype is associated with defects in regulation of phospholipid biosynthesis in yeast. Here we report a screen of the essential yeast gene set using a conditional-expression library. This screen identified novel functions previously unknown to affect phospholipid synthesis.

Keywords: inositol; phospholipid synthesis; regulation; transcription; yeast.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cluster Analysis
  • Genes, Essential*
  • Histone Acetyltransferases / genetics
  • Histone Acetyltransferases / metabolism
  • Inositol / metabolism*
  • Phenotype
  • Phospholipids / biosynthesis
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism


  • Phospholipids
  • Saccharomyces cerevisiae Proteins
  • Inositol
  • Histone Acetyltransferases
  • NuA4 protein, S cerevisiae