Neurologic sequelae following interferon therapy of juvenile laryngeal papilloma

Acta Paediatr Scand. 1988 Jul;77(4):619-22. doi: 10.1111/j.1651-2227.1988.tb10718.x.


Human leukocyte interferon at doses from 2 million units every two days to 3 million units daily was given to a 2-year-old boy for the treatment of recurrent juvenile laryngeal papilloma. After 7 months of treatment the child developed spastic diplegia, which persisted despite the discontinuation of interferon therapy. The clinical picture was consistent with an upper motor neuron lesion; no evidence of peripheral neuropathy was found.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Palsy / etiology*
  • Child, Preschool
  • Humans
  • Interferons / administration & dosage
  • Interferons / adverse effects*
  • Laryngeal Neoplasms / therapy*
  • Male
  • Neoplasm Recurrence, Local / drug therapy*
  • Papilloma / therapy*


  • Interferons