A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety

Complement Ther Med. 2014 Feb;22(1):63-9. doi: 10.1016/j.ctim.2013.11.008. Epub 2013 Dec 5.


Objective: Symptoms of agitation, anxiety and insomnia are frequent among patients with major depressive disorder (MDD) during the first weeks of psychiatric care. But a substantial number of patients declines taking pharmaceutical medication to avoid side effects. Therefore, an alternative herbal medication is needed. Clinical studies demonstrated that lavender oil capsules, termed Lasea®, have an anxiolytic effect comparable to Lorazepam and significantly reduce insomnia and agitation in non-depressed patients. Therefore, the aim of this retrospective case series was to analyze the effectiveness of Lasea® for patients with MDD and symptoms of anxiety, insomnia and psychomotor agitation.

Design: Eight cases were analyzed retrospectively regarding the dosage, length of treatment, possible side effects and effectiveness of Lasea®.

Setting: All cases were treated at the Department of Psychiatry at Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin in a naturalistic setting.

Main outcome measure: Effectiveness was measured by a change in the Hamilton Rating Scale for Depression (HAMD-17) total score and subscores.

Results: In 6 cases, the combination of Lasea® and an antidepressant resulted in a reduction of MDD. Lasea® also reduced agitation in 6 cases. Psychological anxiety was reduced in 5, somatic anxiety in 4 cases whereas sleep-onset and sleep-maintenance insomnia improved in 3 cases each.

Conclusions: The results demonstrate that Lasea® reduces some of the anxiety related symptoms and sleep disturbances in MDD patients. Furthermore Lasea® significantly reduces psychomotor agitation. Additionally, the results indicate a significant global improvement stemming from the combinational therapy of Lasea® and antidepressant medication.

Keywords: Agitation; Anxiety; Herbal pharmacotherapy; Insomnia; Lavendula oil; Major depressive disorder.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antidepressive Agents / therapeutic use*
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / physiopathology
  • Female
  • Health Status Indicators
  • Humans
  • Lavandula
  • Male
  • Middle Aged
  • Oils, Volatile / therapeutic use*
  • Plant Oils / therapeutic use*
  • Psychomotor Agitation / drug therapy*
  • Psychomotor Agitation / physiopathology
  • Retrospective Studies
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Sleep Initiation and Maintenance Disorders / physiopathology


  • Antidepressive Agents
  • Oils, Volatile
  • Plant Oils
  • lavender oil