The role of IP3 receptor channel clustering in Ca2+ wave propagation during oocyte maturation

Prog Mol Biol Transl Sci. 2014:123:83-101. doi: 10.1016/B978-0-12-397897-4.00006-1.

Abstract

During oocyte maturation, the calcium-signaling machinery undergoes a dramatic remodeling resulting in distinctly different calcium-release patterns on all organizational scales from puffs to waves. The dynamics of the Ca(2+) release wave in mature as compared to immature oocytes are defined by a slower propagation speed and longer duration of the high Ca(2+) plateau. In this chapter, we use computational modeling to identify the changes in the signaling machinery, which contribute most significantly to the alterations observed in Ca(2+) wave propagation during Xenopus oocyte maturation. In addition to loss of store-operated calcium entry and internalization of plasma membrane pumps, we propose that spatial reorganization of the IP3 receptors in the plane of the ER membrane is a key factor for the observed signaling changes in Ca(2+) wave propagation.

Keywords: Calcium channels; Calcium signaling; Calcium wave; Inositol 1,4,5, triphosphate receptors; Oocyte maturation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Signaling*
  • Cell Differentiation*
  • Cytosol / metabolism
  • Inositol 1,4,5-Trisphosphate Receptors / metabolism*
  • Intracellular Space / metabolism
  • Oocytes / cytology*
  • Oocytes / metabolism*
  • Ovum
  • Xenopus laevis / metabolism*

Substances

  • Inositol 1,4,5-Trisphosphate Receptors
  • Calcium