Biochemical and Nutritional Markers and Antioxidant Activity in Metabolic Syndrome

Endocrinol Nutr. Jun-Jul 2014;61(6):302-8. doi: 10.1016/j.endonu.2014.01.006. Epub 2014 Feb 18.
[Article in English, Spanish]


Background and objectives: 1) Nutritional assessment of the diet followed by patients with metabolic syndrome, and 2) biochemical analysis of the oxidation-reduction level in patients with metabolic syndrome.

Material and methods: A cross-sectional study was conducted in patients with metabolic syndrome in Murcia. Fifty-three patients, 33 with and 20 without (control group) metabolic syndrome, were selected. The intervention consisted of completion of a recall survey and a test to nutritionally assess dietary intake. Anthropometric and laboratory variables, including those related to antioxidant activity, were also tested.

Results: Antioxidant activity was within normal limits in both groups (1.7 ± 0.2 mmol/L in the control group and 1.8 ± 0.1 mmol/L in the metabolic syndrome group) (NS). Superoxide dismutase levels were not significantly different between the groups. Mean glutathione reductase levels (U/L) were higher in the control group as compared to patients with metabolic syndrome (P<.05). As regards oxidative stress biomarkers, mean isoprostane levels were higher in the control group (4.9 ± 6.2 ng/mL) than in metabolic syndrome patients (3.5 ± 3.9 ng/mL) (P<.05). Oxidized LDL values tended to be higher in metabolic syndrome patients (96 ± 23.2U/L) as compared to the control group (86.2 ± 17.3 U/L), but differences were not significant.

Conclusions: There is a trend to a poorer nutritional and biochemical profile in patients with metabolic syndrome, who also tend to have a greater degree of oxidative stress.

Keywords: Antioxidant; Antioxidante; Isoprostanes; Isoprostanos; Metabolic syndrome; Nutrición; Nutrition; Síndrome metabólico.

MeSH terms

  • Aged
  • Anthropometry
  • Antioxidants / analysis*
  • Biomarkers / blood*
  • Blood Glucose / analysis
  • Blood Proteins / analysis
  • C-Reactive Protein / analysis
  • Cross-Sectional Studies
  • Diet*
  • Female
  • Homocysteine / blood
  • Humans
  • Lipid Peroxidation
  • Lipids / blood
  • Male
  • Metabolic Syndrome / blood*
  • Middle Aged
  • Nutrition Surveys
  • Oxidation-Reduction
  • Oxidative Stress
  • Sampling Studies
  • Spain
  • Urea / blood
  • Uric Acid / blood


  • Antioxidants
  • Biomarkers
  • Blood Glucose
  • Blood Proteins
  • Lipids
  • Homocysteine
  • Uric Acid
  • Urea
  • C-Reactive Protein