Development of antiviral agents toward enterovirus 71 infection

Hamid Reza Pourianfar; Lara Grollo

doi:10.1016/j.jmii.2013.11.011

Development of antiviral agents toward enterovirus 71 infection

J Microbiol Immunol Infect. 2015 Feb;48(1):1-8. doi: 10.1016/j.jmii.2013.11.011. Epub 2014 Feb 21.

Authors

Hamid Reza Pourianfar¹, Lara Grollo²

Affiliations

¹ Iranian Academic Centre for Education, Culture and Research (ACECR)-Mashhad Branch, Mashhad, Iran; Environment and Biotechnology Centre, Swinburne University of Technology, Melbourne, Australia. Electronic address: pourianfar@acecr.ac.ir.
² Environment and Biotechnology Centre, Swinburne University of Technology, Melbourne, Australia.

PMID: 24560700
DOI: 10.1016/j.jmii.2013.11.011

Abstract

Enterovirus 71 (EV71) infection remains a public health problem at a global level, particularly in the Asia-Pacific region. The infection normally manifests as hand-foot-mouth disease; however, it is capable of developing into potentially fatal neurological complications. There is currently no approved vaccine or antiviral substance available for the prevention or treatment of EV71 infection. This paper, thus, reviews efforts to develop or discover synthetic as well as naturally occurring compounds directed against EV71 infection. The recent achievements in cellular receptors of EV71 are also highlighted, and their contribution to the development of antiviral drugs against EV71 is discussed in this article.

Keywords: Antiviral agents; EV71 infection; EV71 receptors; Phytochemicals.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antiviral Agents / isolation & purification*
Antiviral Agents / pharmacology*
Drug Discovery / methods*
Drug Discovery / trends
Enterovirus A, Human / drug effects*
Enterovirus Infections / drug therapy*
Enterovirus Infections / virology*
Humans
Receptors, Virus / drug effects
Receptors, Virus / metabolism

Substances

Antiviral Agents
Receptors, Virus