Lymphangiogenesis and lymphatic vessel remodelling in cancer

Nat Rev Cancer. 2014 Mar;14(3):159-72. doi: 10.1038/nrc3677.


The generation of new lymphatic vessels through lymphangiogenesis and the remodelling of existing lymphatics are thought to be important steps in cancer metastasis. The past decade has been exciting in terms of research into the molecular and cellular biology of lymphatic vessels in cancer, and it has been shown that the molecular control of tumour lymphangiogenesis has similarities to that of tumour angiogenesis. Nevertheless, there are significant mechanistic differences between these biological processes. We are now developing a greater understanding of the specific roles of distinct lymphatic vessel subtypes in cancer, and this provides opportunities to improve diagnostic and therapeutic approaches that aim to restrict the progression of cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphangiogenesis*
  • Lymphatic Vessels / metabolism
  • Lymphatic Vessels / pathology
  • Lymphatic Vessels / physiopathology*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Neovascularization, Pathologic