Sex hormone drives blood stem cell reproduction

EMBO J. 2014 Mar 18;33(6):534-5. doi: 10.1002/embj.201487976. Epub 2014 Feb 20.


Stem cells ensure the maintenance of tissue homeostasis throughout life by tightly regulating their self-renewal and differentiation. In a recent study published in Nature, Nakada et al, 2014 unveil an unexpected endocrine mechanism that regulates hematopoietic stem cell (HSC) self-renewal.

Publication types

  • Comment

MeSH terms

  • Animals
  • Estrogens / metabolism*
  • Female
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism*
  • Male
  • Pregnancy


  • Estrogens