Condensins and 3D Organization of the Interphase Nucleus

Curr Genet Med Rep. 2013 Dec 1;1(4):219-229. doi: 10.1007/s40142-013-0024-4.


Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins are involved in chromatin organization, gene expression, and DNA repair and indicates similarities between the interphase and mitotic functions of condensin. Recent work has enhanced our knowledge of how chromatin architecture is dynamically regulated by condensin to impact essential cellular processes.

Keywords: Chromatin; Chromosome condensation; Condensin; Interphase chromosome; Nuclear organization; SMC proteins.