The proteasome and the degradation of oxidized proteins: part III-Redox regulation of the proteasomal system

Redox Biol. 2014 Jan 14;2:388-94. doi: 10.1016/j.redox.2013.12.029. eCollection 2014.

Abstract

Here, we review shortly the current knowledge on the regulation of the proteasomal system during and after oxidative stress. After addressing the components of the proteasomal system and the degradation of oxidatively damaged proteins in part I and II of this series, we address here which changes in activity undergo the proteasome and the ubiquitin-proteasomal system itself under oxidative conditions. While several components of the proteasomal system undergo direct oxidative modification, a number of redox-regulated events are modulating the proteasomal activity in a way it can address the major tasks in an oxidative stress situation: the removal of oxidized proteins and the adaptation of the cellular metabolism to the stress situation.

Keywords: 20S proteasome; Jak/Stat; Nrf2; PARP1; Ubiquitin–proteasome-system.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Janus Kinases / metabolism
  • Models, Molecular
  • NF-E2-Related Factor 2 / metabolism
  • Oxidation-Reduction
  • Oxidative Stress / physiology*
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases / metabolism
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Conformation
  • Proteolysis*
  • STAT Transcription Factors / metabolism
  • Ubiquitin / metabolism

Substances

  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • STAT Transcription Factors
  • Ubiquitin
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • Janus Kinases
  • Proteasome Endopeptidase Complex