Mung bean decreases plasma cholesterol by up-regulation of CYP7A1

Plant Foods Hum Nutr. 2014 Jun;69(2):134-6. doi: 10.1007/s11130-014-0405-1.

Abstract

Our results affirmed that supplementation of 1 or 2% mung bean could decrease plasma total cholesterol and triacylglycerol level. Mung bean increased mRNA 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Most importantly, mung bean increased not only the protein level of cholesterol-7α-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of mung bean was most probable mediated by enhancement of bile acid excretion and up-regulation of CYP7A1.

MeSH terms

  • Animals
  • Anticholesteremic Agents / pharmacology*
  • Cholesterol / blood*
  • Cholesterol 7-alpha-Hydroxylase / genetics
  • Cholesterol 7-alpha-Hydroxylase / metabolism*
  • Cholesterol, HDL / metabolism
  • Cricetinae
  • Fabaceae*
  • Feces
  • Liver / drug effects
  • Liver / metabolism
  • Liver X Receptors
  • Orphan Nuclear Receptors / genetics
  • Orphan Nuclear Receptors / metabolism
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism
  • Sterol Regulatory Element Binding Protein 2 / genetics
  • Sterol Regulatory Element Binding Protein 2 / metabolism
  • Sterols / pharmacokinetics
  • Triglycerides / blood
  • Up-Regulation

Substances

  • Anticholesteremic Agents
  • Cholesterol, HDL
  • Liver X Receptors
  • Orphan Nuclear Receptors
  • Receptors, LDL
  • Sterol Regulatory Element Binding Protein 2
  • Sterols
  • Triglycerides
  • Cholesterol
  • Cholesterol 7-alpha-Hydroxylase