Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members

Dis Markers. 1988 Jun;6(2):127-32.

Abstract

Detailed chromosome analysis failed to reveal any evidence for spontaneous chromosome instability in lymphocytes from patients with multiple endocrine neoplasia, type 2 (MEN-2), whereas, with one exception, lymphocytes from MEN-2 patients were significantly more sensitive to chromosome damage by bleomycin and, to a lesser extent, MNNG than those from controls. The exceptional case suggests possible genetic heterogeneity in MEN-2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bleomycin / pharmacology
  • Carcinoma / genetics*
  • Chromosome Aberrations*
  • Humans
  • Lymphocytes / analysis*
  • Lymphocytes / drug effects
  • Methylnitronitrosoguanidine / pharmacology
  • Multiple Endocrine Neoplasia / genetics*
  • Thyroid Neoplasms / genetics*

Substances

  • Bleomycin
  • Methylnitronitrosoguanidine