Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila

EMBO J. 1988 Apr;7(4):1087-96.


The Shaker locus of Drosophila contains a very large transcription unit. It is expressed predominantly in the nervous system by multiple, differential as well as alternative, splicing mechanisms into different, but functionally related proteins. The structure of the Shaker transcription unit and the properties of the encoded Shaker protein family provide a molecular basis for A channel diversity in excitable cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Drosophila / genetics*
  • Drosophila / metabolism
  • Genes*
  • Ion Channels / metabolism*
  • Molecular Sequence Data
  • Mutation*
  • Nervous System / metabolism
  • Potassium / metabolism*
  • Transcription, Genetic


  • Ion Channels
  • Potassium

Associated data

  • GENBANK/X07131
  • GENBANK/X07132
  • GENBANK/X07133
  • GENBANK/X07134
  • GENBANK/Y00847