Intratumoral heterogeneity in kidney cancer

Nat Genet. 2014 Mar;46(3):214-5. doi: 10.1038/ng.2904.


Clear cell renal cell carcinoma (CCRCC) is characterized by mutation of the VHL gene and loss of a segment of chromosome 3. A new study using multi-region exome sequencing has identified substantial intratumoral heterogeneity within large primary CCRCCs, which has profound implications for understanding tumor evolution and for developing effective therapies.

Publication types

  • News

MeSH terms

  • Carcinoma, Renal Cell / etiology
  • Carcinoma, Renal Cell / genetics*
  • Carcinoma, Renal Cell / metabolism
  • Humans
  • Kidney Neoplasms / etiology
  • Kidney Neoplasms / genetics*
  • Kidney Neoplasms / metabolism
  • Mutation
  • Von Hippel-Lindau Tumor Suppressor Protein / genetics


  • Von Hippel-Lindau Tumor Suppressor Protein
  • VHL protein, human